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Role of NSAIDs in acute treatment of headache
Author(s) -
Martelletti Paolo,
Farinelli Ivano,
Coloprisco Gabriella,
Patacchioli Francesca Romana
Publication year - 2007
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20191
Subject(s) - medicine , migraine , nonsteroidal , drug , anesthesia , acute migraine , intensive care medicine , chronic migraine , vascular headache , population , pharmacology , alternative medicine , pathology , placebo , environmental health
Headache is one of the most common neurological disorders worldwide. Tension‐type headache (TTH) represents the most frequent headache form, involving 82% of sufferers. Of this population, 14% are affected by migraine and 4% by a chronic form of headache (chronic daily headache [CDH]). Nonsteroidal anti‐inflammatory drugs (NSAIDs) represent the most used acute therapy for TTH and migraine because of issues with coxibs safety. NSAIDs play a minor role is the treatment in trigeminal‐autonomic cephalgias (TACs); if excluding indomethacin in the acute management of paroxysmal hemicrania (PH). Despite limitations in their utilization, NSAIDs still constitute drugs of primary importance, being effective and being well tolerated in the treatment of acute episodes. Drug Dev Res 68:276–281, 2007. © 2007 Wiley‐Liss, Inc.