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Hypertension, diabetes, insulin resistance, and postprandial hyperglycemia
Author(s) -
Bell David S.H.
Publication year - 2006
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20130
Subject(s) - medicine , hyperinsulinemia , postprandial , diabetes mellitus , insulin resistance , insulin , heart failure , endocrinology , cardiology , blood pressure
Diabetes is associated with an increased risk of cardiac events and congestive heart failure. The improvement in outcomes for mortality in non‐diabetic subjects over the last decade has not been matched in the diabetic patient. This may be due to a failure to intensify therapy in the diabetic patient. An essential part of this intensification includes treatment of hypertension. Lower blood pressure levels in the diabetic patient have been shown to be associated with a lower rate of cardiovascular events. Both hyperglycemia and hyperinsulinemia due to insulin resistance are responsible for the increased prevalence of hypertension in the type 2 diabetic subject. Even non‐diabetic insulin‐resistant hypertensive subjects have higher post‐prandial glucoses. The higher the post‐prandial glucose, the greater is the risk of atherosclerosis, and lowering of post‐prandial glucoses results in less cardiac events. Drug Dev. Res. 67:595–596, 2006. © 2006 Wiley‐Liss, Inc.