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Magnetic nanoparticles for drug delivery
Author(s) -
Dobson Jon
Publication year - 2006
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20067
Subject(s) - drug delivery , magnetic nanoparticles , targeted drug delivery , nanotechnology , biocompatible material , in vivo , nanoparticle , nanomedicine , drug , pharmacology , materials science , medicine , biomedical engineering , biology , microbiology and biotechnology
Targeting specific sites in vivo for the delivery of therapeutic compounds presents a major obstacle to the treatment of many diseases. One targeted delivery technique that has gained prominence in recent years is the use of magnetic nanoparticles. In these systems, therapeutic compounds are attached to biocompatible magnetic nanoparticles and magnetic fields generated outside the body are focused on specific targets in vivo. The fields capture the particle complex resulting in enhanced delivery to the target site. This review will focus on technical aspects of magnetic targeting as well as nanoparticle design and animal and clinical trials. Drug Dev. Res. 67:55–60, 2006. © 2006 Wiley‐Liss, Inc.