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Amphiphilic block copolymer micelles for nanoscale drug delivery
Author(s) -
Kwon Glen S.,
Forrest M. Laird
Publication year - 2006
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20063
Subject(s) - micelle , amphiphile , drug , drug delivery , solubilization , copolymer , chemistry , pulmonary surfactant , biocompatibility , drug carrier , targeted drug delivery , nanotechnology , pharmacology , combinatorial chemistry , materials science , organic chemistry , aqueous solution , medicine , biochemistry , polymer
Amphiphilic block copolymers can assemble into supramolecular core‐shell structures, termed ABC micelles, that have proven utility in drug delivery, particularly for drug solubilization. Several examples have entered clinical trials, attesting to the biocompatibility of ABCs and the potential advantages for drug delivery, e.g., low toxicity relative to Cremophor ® EL, a surfactant commonly used for drug solubilization. Several examples of ABC micelles demonstrate potential for prolonged circulation in blood. Coupled with novel strategies toward controlled release of drug, nanoscale ABC micelles have tremendous potential for the targeting of antitumor agents, many of which are poorly water soluble and possess dose‐limiting toxicity. Drug Dev. Res. 67:15–22, 2006. © 2006 Wiley‐Liss, Inc.