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Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR
Author(s) -
Cegelski Lynette,
Rice Charles V.,
O'Connor Robert D.,
Caruano Amy L.,
Tochtrop Gregory P.,
Cai Zu Yun,
Covey Douglas F.,
Schaefer Jacob
Publication year - 2005
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20048
Subject(s) - neuroprotection , estradiol benzoate , phospholipid , estrogen , chemistry , pharmacology , lipid bilayer , medicine , biochemistry , membrane , ovariectomized rat
Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke‐related brain damage, Alzheimer's disease, and Parkinson's disease. 13 C{ 31 P} and 13 C{ 19 F} rotational‐echo double‐resonance NMR have been used to map the locations of 17β‐estradiol (estradiol), 17β‐estradiol 17‐benzoate (estradiol benzoate), and 17β‐2‐(1‐adamantyl)estradiol (adamantyl estradiol) in 19 F‐labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency. Drug Dev. Res. 66:99–102, 2006. © 2006 Wiley‐Liss, Inc.