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Monoamine reuptake inhibitors: highlights of recent research developments
Author(s) -
Walter Magnus W.
Publication year - 2005
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20013
Subject(s) - monoamine neurotransmitter , reuptake , reuptake inhibitor , norepinephrine transporter , norepinephrine , pharmacology , medicine , serotonin , dopamine , receptor
Monoamine reuptake inhibitors are in clinical use for the treatment of major psychiatric disorders. Selective serotonin reuptake inhibitors are widely used in the treatment of depression. Selective norepinephrine reuptake inhibitors are used in the treatment of ADHD and depression. Compounds that enhance multiple monoamines appear to have synergistic effects and have been used for various indications. This review presents highlights from the literature on monoamine reuptake inhibitors published between 2000 and July 2005. It focuses on novel structure‐activity relationship studies in established classes of monoamine reuptake inhibitors and structurally novel types. Drug Dev. Res. 65:97–118, 2005. © 2005 Wiley‐Liss, Inc.