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Prophylactic effects of caprine serum factor (CSF‐I) in mice infected with Salmonella typhimurium
Author(s) -
Willeford Kenneth O.,
Parker Todd A.,
Pharr G. Todd,
Buddington Karyl
Publication year - 2001
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.1204
Subject(s) - salmonella , titer , prophylactic treatment , medicine , microbiology and biotechnology , ratón , pharmacology , immunology , biology , antibody , bacteria , genetics
Administration of caprine serum fraction–immunomodulator (CSF‐I) resulted in an enhanced survival rate in female Swiss Webster mice infected with approximately 5,000 colony‐forming units of Salmonella typhimurium . The prophylactic benefit of CSF‐I resulted in a significant reduction in mortality of treated mice vs. control mice. Dependent upon the inoculum’s titer, 80–90% of the control group was lost due to salmonellosis by 8 days postchallenge. A single 0.1 ml (3 mg) subcutaneous dose of CSF‐I given 1 day before challenge improved the survival by 70–80% and dramatically reduced the presence of S. typhimurium in splenic tissue. No prophylactic benefits were observed if CSF‐I was given 4 days in advance of the pathogenic challenge. The prophylactic benefits of CSF‐I developed in a dose‐dependent manner. CSF‐I enhances the ability of the host to withstand and survive the challenge of an infectious agent. Drug Dev. Res. 54:45–51, 2001. © 2001 Wiley‐Liss, Inc.