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Immunosuppressive effects of extracellular adenosine on immune cells: Implications for the pathogenesis of ADA SCID and immunomodulation
Author(s) -
Gomez Gregorio,
Apasov Sergey,
Sitkovsky Michail V.
Publication year - 2001
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.1190
Subject(s) - adenosine , extracellular , adenosine receptor , pathogenesis , immune system , mediator , purinergic signalling , biology , adenosine kinase , adenosine a3 receptor , pharmacology , immunology , receptor , microbiology and biotechnology , adenosine deaminase , endocrinology , biochemistry , agonist
Signaling through extracellular adenosine receptors is believed to account for the wide‐ranging effects of adenosine. Interest of immunologists in adenosine stems from the observation that ADA deficiency leads to the inheritable SCID syndrome, and the data reviewed here indicate that at least some of the characteristics of ADA‐SCID may be a consequence of extracellular adenosine signaling. Studies of adenosine receptor and ADA‐deficient mice may provide the genetic evidence necessary to implicate extracellular adenosine as an important mediator in pathogenesis of ADA SCID and in demonstration of selectivity of adenosine‐based immunomodulating drugs. Drug Dev. Res. 53:218–224, 2001. Published 2001 Wiley‐Liss, Inc.