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Pharmacogenomics in Cardiovascular Medicine
Author(s) -
Carlquist John F.,
Anderson Jeffrey L.
Publication year - 2004
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10355
Subject(s) - pharmacogenomics , medicine , drug , translational medicine , pharmacogenetics , psychosocial , personalized medicine , precision medicine , intensive care medicine , pharmacology , bioinformatics , gene , biology , psychiatry , genetics , pathology , genotype
The completion of the Human Genome Project (HGP) holds promise for further insight into how genetic differences contribute to an individual's response to a medicine(s). Even before the completion of the HGP, cardiovascular medicine was thrust into the arena of pharmacogenomics by the observation that many drugs, cardiovascular and noncardiovascular, promote cardiac arrhythmias. It is now recognized that these adverse responses as well as beneficial responses to cardiovascular medicines can be influenced by alterations in the genes for metabolizing enzymes, drug transporters, and drug targets. To the present, much basic information regarding gene–drug interactions has accumulated, but translation to clinical care has been slow. It is anticipated that the pace of clinical cardiovascular pharmacogenomics will increase as the result of better‐designed studies and technological advances. The final adoption of this area of investigation into clinical practice will also be influenced by financial, psychosocial, and legal factors. Drug Dev. Res. 62:180–190, 2004. © 2004 Wiley‐Liss, Inc.