Proteinase‐activated receptors (PARs) and immune function | Zendy

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Proteinase‐activated receptors (PARs) and immune function

Author(s) -

Fiorucci Stefano,

Distrutti Eleonora

Publication year - 2003

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.10322

Subject(s) - protease activated receptor , microbiology and biotechnology , thrombin , tryptase , receptor , innate immune system , extracellular matrix , chemokine , immune system , cytokine , monocyte , coagulation , biology , chemistry , immunology , biochemistry , medicine , platelet , mast cell

Proteinase‐activated receptors (PARs) function as cell sensors for proteinases. Expression of PARs in immune cells suggests a role in innate immunity. PAR 1 mediates the cellular effects of thrombin and causes cytokine and chemokine production by endothelial cells and macrophages. Expression of PAR 1 on fibroblasts mediates the profibrogenic activity of thrombin and triggers extracellular matrix protein deposition. PAR 2 activation by trypsin, tryptase, and coagulation proteinases triggers both pro‐ and antiinflammatory activities by regulating monocyte recruitment/activation in inflamed tissues. Drug Dev. Res. 60:65–70, 2003. © 2003 Wiley‐Liss, Inc.

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