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Upregulation of proteinase‐activated receptors (PARs) and cardiovascular function
Author(s) -
Cirino Giuseppe,
Cicala Carla
Publication year - 2003
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10315
Subject(s) - downregulation and upregulation , receptor , thrombin , inflammation , protease activated receptor , function (biology) , neuroscience , microbiology and biotechnology , biology , medicine , immunology , biochemistry , platelet , gene
Proteinase activated receptors (PARs) have attracted particular attention for their possible role in cardiovascular physiology and disease. The aim of this article is to review what is known up to now about the upregulation of PARs that are targets for thrombin (PARs 1, 3, and 4) and PAR 2 , which is not activated by thrombin. Particular emphasis will be given to what is the “state of the art” on the upregulation of these receptors within the cardiovascular system and their relationship to those phenomena that can be encompassed under the term “cardiovascular inflammation.“ Drug Dev. Res. 60:20–23, 2003. © 2003 Wiley‐Liss, Inc.