Modulation of gastric function by proteinase‐activated receptors | Zendy

Nishikawa Hiroyuki | Zendy; Kawabata Atsufumi | Zendy

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Modulation of gastric function by proteinase‐activated receptors

Author(s) -

Nishikawa Hiroyuki,

Kawabata Atsufumi

Publication year - 2003

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.10313

Subject(s) - gastric mucosa , receptor , pepsin , mucus , secretion , endocrinology , gastric acid , medicine , biology , contraction (grammar) , chemistry , stomach , biochemistry , enzyme , ecology

Proteinase‐activated receptor (PAR) 1 and PAR 2 are abundantly expressed in the gastric mucosa and smooth muscle. PAR 2 modulates a variety of gastric functions, mediating secretion of mucus and pepsinogen, suppression of acid output, an increase in mucosal blood flow, and smooth muscle contraction/relaxation. PAR 2 is considered primarily protective in the gastric mucosa. PARs other than PAR 2 might also be involved in the modulation of gastric functions. PARs, especially PAR 2 , would thus appear to be novel targets for the development of drugs for treatment of gastric mucosal diseases. Drug Dev. Res. 60:9–13, 2003. © 2003 Wiley‐Liss, Inc.

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