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Proteinase‐activated receptors (PARs): An evolving hormonal system
Author(s) -
Hollenberg Morley D.
Publication year - 2003
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10300
Subject(s) - receptor , g protein coupled receptor , drug discovery , molecular pharmacology , biology , drug development , signal transduction , thrombin , hormone , neuroscience , computational biology , microbiology and biotechnology , drug , pharmacology , bioinformatics , biochemistry , immunology , platelet
An overview of the articles presented in this two‐part special issue of Drug Development Research is provided here. This two‐part series focuses on the discovery, molecular pharmacology, and physiology of the Proteinase‐activated Receptor (PAR) family. This recently discovered G‐protein‐coupled receptor family mediates the signaling properties of a number of serine proteinases, including thrombin. PARs are responsible for a variety of physiological roles that proteinases may now be seen to play in their capacity as “signaling molecules.” It is the aim of the Special Issue articles to illustrate PARs' unique pharmacological properties and to alert the scientific community to the widespread physiological roles this receptor family can play in a variety of settings. Drug Dev. Res. 59:334–335, 2003. © 2003 Wiley‐Liss, Inc.