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Extracellular ATP, P2 receptors, and inflammation
Author(s) -
Virgilio Francesco Di,
Ferrari Davide,
Idzko Marco,
Panther Elisabeth,
Norgauer Johannes,
Sala Andrea la,
Girolomoni Giampiero
Publication year - 2003
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10191
Subject(s) - receptor , inflammation , proinflammatory cytokine , immune system , extracellular , immune receptor , cytokine , microbiology and biotechnology , immunology , chemotaxis , antigen presentation , cytotoxic t cell , biology , chemistry , t cell , biochemistry , in vitro
Over the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the very heart of the initiation of the immune response, i.e., antigen presentation by dendritic cells. Drug Dev. Res. 59:171–174, 2003. © 2003 Wiley‐Liss, Inc.