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Development of antiinflammatory therapy for Alzheimer's disease
Author(s) -
Aisen Paul S.
Publication year - 2002
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10094
Subject(s) - disease , medicine , clinical trial , alzheimer's disease , drug development , epidemiology , drug , randomized controlled trial , pharmacology
Inflammatory mechanisms are active in the Alzheimer's disease (AD) brain. Studies that range from epidemiological surveys to therapeutic trials in transgenic mice provide growing support for the theory that antiinflammatory drugs may be useful in the prevention and/or treatment of the disease. Randomized controlled trials in humans have not yet confirmed this theory. However, prevention and treatment trials continue to test specific antiinflammatory strategies for AD. Drug Dev. Res. 56:421–427, 2002. © 2002 Wiley‐Liss, Inc.