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Septic shock induced by microbial products and indomethacin
Author(s) -
Moriya Keisuke,
Ohno Naohito,
Miura Noriko N.,
Adachi Yoshiyuki,
Yadomae Toshiro
Publication year - 2002
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10046
Subject(s) - toxicity , pharmacology , bacteria , septic shock , antibiotics , acute toxicity , sepsis , microbiology and biotechnology , shock (circulatory) , ratón , biology , chemistry , medicine , immunology , genetics
Lethal toxicity was induced in mice by sequential administration of β‐glucan and indomethacin. Whole cell preparations of Gram‐positive bacteria, Gram‐negative bacteria, and fungi also showed a similar toxicity. However, bacterial lipopolysaccharides (LPS) alone were not toxic. After the indomethacin administration, the sensitivity of mice to LPS was significantly elevated and the animals died following only a 0.1‐μg intravenous administration. An accumulation of leukocytes in the liver and enhancement of TNF, IL‐6, and MIP‐2 concentrations were noted. Antibiotic treatment prolonged the survival of mice. The toxicity resembles septic shock, and is strongly related to microbial translocation and endotoxin absorption from the gut. Drug Dev. Res. 55:139–148, 2002. © 2002 Wiley‐Liss, Inc.