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Therapeutic Na + channel blockers beneficial for pain syndromes
Author(s) -
Wang Ging Kuo,
Strichartz Gary R.
Publication year - 2001
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.10014
Subject(s) - sodium channel , neuropathic pain , blockade , medicine , sodium channel blocker , pharmacology , drug , chronic pain , anesthesia , neuroscience , sodium , chemistry , psychology , physical therapy , receptor , organic chemistry
Abstract A variety of drugs are used to prevent or treat pain and many of them are known to inhibit the activity of the voltage‐gated sodium channels (VGSCs) required for neuronal excitability. In this overview, we consider the current status and future prospects for these drugs used in two contexts: local application for acute and prolonged blockade of impulses in peripheral nerve, and systemic administration for the relief of chronic pain of metabolic, neuropathic, or cancer origin. Drug Dev. Res. 54:154–158, 2002. © 2002 Wiley‐Liss, Inc.