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Cytodiagnosis of parvoviruS b19 infection from ascites fluid of hydrops fetalis: Report of a case
Author(s) -
Iwa Nobuzo,
Yutani Chikao
Publication year - 1995
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840130212
Subject(s) - parvovirus , hydrops fetalis , parvoviridae , pathology , medicine , ascites , fetus , ascitic fluid , autopsy , papanicolaou stain , cytopathology , antigen , virology , cytology , virus , immunology , pregnancy , biology , cancer , cervical cancer , genetics , gastroenterology
The cytologic changes in the smears of fetus ascites fluid with parvovirus B19 infections are described. Cytology revealed the ground‐glass appearance of the nuclei having a perinuclear halo, and the nuclear chromatin was spread as a thin rim around the inclusion. Subsequently, monoclonal antibodies for parvovirus B19 were applied to identify the specific antigen in the Papanicolaou‐destained specimens. Positive staining reaction products were found throughout the cytoplasm of cells. Similar phenomena were confirmed in paraffin‐embedded tissue sections of many organs in autopsy materials. It is hoped that recognition of those virus‐infected cells in the body cavity fluid of the fetus will be helpful in making a diagnosis of hydrops fetalis associated with parvovirus B19 infections of the pregnant woman. © 1995 Wiley‐Liss, Inc.