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Fine‐needle aspiration biopsy diagnosis of extrarenal malignant rhabdoid tumor
Author(s) -
Akhtar Mohammed,
Kfoury Hala,
Haider Abdulrazzaq,
Sackey Kwesi,
Ali M. Ashraf
Publication year - 1994
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840110315
Subject(s) - pathology , fine needle aspiration , cytokeratin , vimentin , biopsy , medicine , cytoplasm , nucleolus , immunohistochemistry , cytoplasmic inclusion , aspiration biopsy , electron microscope , cytopathology , cytology , biology , biochemistry , physics , optics
Two cases of extrarenal malignant rhabdoid tumors are presented in which diagnosis was suggested by fine‐needle aspiration biopsy and confirmed by histologic and electron microscopic examination. Fine‐needle aspiration smears in both cases revealed round to polygonal cells with vesicular nuclei and prominent nucleoli. Several tumor cells contained cytoplasmic inclusions composed of intermediate filaments. A majority of the tumor cells stained strongly for vimentin and cytokeratin. Electron microscopic examination revealed many cells with large aggregates of intermediate filaments corresponding to the cytoplasmic inclusions. Fine‐needle aspiration biopsy may be used for diagnosing malignant rhabdoid tumor. The diagnosis may be further confirmed by immunohistochemistry and electron microscopy. Diagn Cytopathol 1994;11:271–276. © 1994 Wiley‐Liss, Inc.