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Small round cell tumor with divergent differentiation: Cytologic, histologic, and ultrastructural findings
Author(s) -
Akhtar Mohammed,
Ali Muhammad Ashraf,
Sabbah Rajeh,
Bakry Mohammed,
AlDayel Fouad
Publication year - 1994
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840110210
Subject(s) - pathology , vimentin , cytokeratin , desmin , immunohistochemistry , ultrastructure , cytology , medicine , biopsy , intermediate filament , cytoplasm , tumor cells , cytopathology , cell , biology , cytoskeleton , microbiology and biotechnology , cancer research , genetics
A case study of desmoplastic small round cell tumor with divergent differentiation in a 13‐yr‐old boy is presented. Clinical, cytologic, histologic, immunohistochemical, and ultrastructural findings are reported. There was a close correlation between the various histologic and cytologic patterns. Immunohistochemical studies revealed strong positivity of many of the tumor cells for cytokeratin, vimentin, and desmin. Ultrastructurally, some of the tumor cells contained aggregates of cytoplasmic intermediate filaments. Fine‐needle aspiration biopsy may suggest the diagnosis of desmoplastic small round cell tumor. Confirmation of the diagnosis may be provided by immuhistochemistry and electronmicroscopy. Diagn Cytopathol 1994; 11:159–164. © 1994 Wiley‐Liss, Inc.