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Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: A potential diagnostic pitfall with fine‐needle aspiration cytology
Author(s) -
Wax Tim D.,
Layfield Lester J.,
Zaleski Sue,
Bhargara Vivek,
Cohen Michael,
Lyerly Herbert K.,
Fisher Samuel R.
Publication year - 1994
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840100216
Subject(s) - sialadenitis , medicine , papanicolaou stain , cytomegalovirus , fine needle aspiration , pathology , cytopathology , differential diagnosis , cytology , biopsy , salivary gland , human immunodeficiency virus (hiv) , viral disease , virology , herpesviridae , cancer , cervical cancer
We report three cases of cytomegalovirus (CMV) sialadenitis which presented as parotid gland nodules in patients infected with the human immunodeficiency virus. While CMV is known to widely infect patients with the acquired immunodeficiency syndrome (AIDS), we are aware of only a single report of CMV sialadenitis in a patient with AIDS (Pialoux et al.: Rev Infect Dis 1991;13:338). Utilizing fine‐needle aspiration (FNA) cytology as the initial investigative modality, two cases were correctly diagnosed preoperatively while the third case displayed atypical features and was interpreted erroneously as carcinoma leading to surgical intervention. Upon review of these cases of CMV sialadenitis, the characteristic intranuclear inclusions are best identified with Papanicolaou (Pap) staining. CMV sialadenitis should be considered in the differential diagnosis of painless salivary gland enlargement in patients with AIDS. We believe this lesion can be diagnosed preoperatively with FNA and the interpretation is aided by evaluating both Pap‐ and Giemsa‐stained material. © 1994 Wiley‐Liss, Inc.