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Sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease): Cytomorphologic analysis on fine‐needle aspirates
Author(s) -
Schmitt Fernando C.
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080612
Subject(s) - sinus histiocytosis with massive lymphadenopathy , medicine , pathology , rosai–dorfman disease , histiocyte , histiocytosis , biopsy , fine needle aspiration , emperipolesis , disease
Cytomorphologic characteristics of smears from fine‐needle aspirates (FNA) of three cases of sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai‐Dorfman disease) are described. All aspirates showed mature lymphocytes, plasma cells, and large pale histiocytes with well‐preserved lymphocytes within the cytoplasm (lymphocytophagocytosis). The cases were confirmed by surgical biopsy, and the immunohistochemical findings suggested a macrophage origin for this lesion. The value of FNA analysis as an aid to diagnosis of SHML is discussed.