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Fine‐needle aspiration biopsy of hepatic angiosarcoma: Report of a case with immunocytochemical findings
Author(s) -
Wong John W.,
Bedard Yvan C.
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080416
Subject(s) - medicine , carcinoembryonic antigen , pathology , vimentin , angiosarcoma , biopsy , malignancy , fine needle aspiration , cytokeratin , sarcoma , cancer , immunohistochemistry
Hepatic angiosarcoma (Kupffer cell sarcoma) is a very rare but ominous malignancy. We report a case diagnosed by fine‐needle aspiration biopsy (FNAB). The smear showed malignant spindle cells and a few rounded cells. The diagnosis was made on the cell block by the characteristic scaffolding arrangement of malignant cells along preexisting hepatocytes. This is the first report with immunocytochemical findings. The tumour cells stained positively for vimentin and negatively for keratin, factor VIII, Ulex europaeus agglutinin I (UEA‐1), carcinoembryonic antigen (CEA), alpha‐fetoprotein (AFP), and lysozyme. This case demonstrates the possibility of a definitive diagnosis by FNAB prior to death without inflicting serious complications.