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Malignant rhabdoid tumor of soft tissues: A cytopathological and immunohistochemical study
Author(s) -
Sola Pérez J.,
PérezGuillermo M.,
Bas Bernal A.,
Manzanera López T.,
Caro López F.
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080413
Subject(s) - immunohistochemistry , pathology , vimentin , desmin , nucleolus , keratin , cytoplasm , cytoplasmic inclusion , hyaline , medicine , cytokeratin , differential diagnosis , biology , microbiology and biotechnology
We describe the cytopathological and immunohistochemical features of a primary malignant rhaboid tumor (MRT) located in the left forehead region of an 8‐mo‐old female. The cardinal characteristics are hyaline cytoplasmic inclusions, rounded or bean‐shaped nucleus, vesicular chromatin, central prominent nucleolus, and poorly defined cytoplasmic profile. Both the cytoplasm and the hyaline inclusion are vimentin and keratin positive, but negative with desmin, S‐100 protein, neuron‐specific enolase, (NSE) myoglobin, leukocyte common antigen (LCA), and alpha‐1‐antichymotrypsin. This immunohistochemical pattern, although not exclusive to MRT, is fairly typical of MRT, and when it is assessed in conjunction with cytopathological findings and clinical data permits a confident diagnosis of MRT. We emphasize the utility of immunohistochemical techniques in making the differential diagnosis of MRT against other childhood round‐Cell tumors. © 1992 Wiley‐Liss, Inc.