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Electron microscopy of fine‐needle aspiration biopsy specimens: A brief review
Author(s) -
Akhtar Mohammed,
Bakry Mohammed,
AlJeaid Aziza Saad,
McClintock Jeffrey A.
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080317
Subject(s) - fine needle aspiration , medicine , biopsy , electron microscope , microscopy , pathology , filtration (mathematics) , sieve (category theory) , transmission electron microscopy , materials science , nanotechnology , optics , statistics , physics , mathematics , combinatorics
The cellular sample obtained by fine‐needle aspiration biopsy is usually small and therefore requires extreme care during processing for electron microscopy. The most significant technical problem is due to contamination of the sample by red blood cells, which tend to dilute the samples. Red blood cells in these samples may be removed prior to processing by either using Bovine serum albumin as a gradient or by filtration of the specimen by a nylon sieve. Experience at our institution with the use of electron microscopy for interpretation of fine‐needle aspiration biopsy samples is briefly reviewed. © 1992 Wiley‐Liss, Inc.