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Fine‐needle aspiration biopsy of pediatric neoplasms: Correlation between electron microscopy and immunocytochemistry in diagnosis and classification
Author(s) -
Akhtar Mohammed,
Bedrossian Carlos W. M.,
Ali Muhammad Ashraf,
Bakry Mohammed
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080314
Subject(s) - medicine , pathology , fine needle aspiration , rhabdomyosarcoma , biopsy , sarcoma , neuroblastoma , cytopathology , immunocytochemistry , retinoblastoma , lymphoma , aspiration biopsy , radiology , cytology , biochemistry , chemistry , biology , gene , genetics , cell culture
A series of fine‐needle aspiration biopsies performed in 635 children were reviewed. The diagnoses rendered in these patients included malignant lymphoma in 139 (21.9%); Hodgkin 's disease, 25 (3.9%); neuroblastoma, 58 (9.1%); Wilms' Tumor, 37 (5.8%); Ewing's sarcoma, 32 (5.0%); rhabdomyosarcoma, 25 (3.9%); retinoblastoma, 22 (3.5%); leukemia infiltrate, 33 (5.2%); and miscellaneous tumors, 52 (8.2%). In 171 patients (26.9%), the biopsy was nondiagnostic. The cytomorphological characteristics of these lesions are briefly described and illustrated. Salient morphological features are further correlated with histological and ultrastructural appearances. Immunocytochemical patterns of these tumors are also discussed briefly. © 1992 Wiley‐Liss, Inc.