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Cytology of transitional‐cell carcinoma of the urinary bladder: Diagnostic yield and histologic basis
Author(s) -
Dibonito Luigi,
Musse Mohamed Moallim,
Dudine Sandra,
Falconieri Giovanni
Publication year - 1992
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840080207
Subject(s) - medicine , cytology , pleomorphism (cytology) , atypia , transitional cell carcinoma , urinary bladder , pathology , carcinoma , urology , urinary system , bladder cancer , cancer , immunohistochemistry
The diagnostic yield of cytology in histologically proven transitional‐cell carcinoma (TCC) of the urinary bladder has been studied in 100 cases. Cytohistologic correlation rates were 20 percent, 61.7 percent, and 92.8 percent, respectively, for grade 1, 2, and 3 tumors. When further evaluated, G2 cases were segregated into 2 subcategories, G2a and G2b, based on histologic preservation of nuclear polarity, pleomorphism, and other cellular irregularities. Correlation rates were rather low for G2a cases (6/18, 33%) and high for G2b cases, (23/29; 79%). The prevalence of atypical cells was 2 (11.1%) cases in G2a and 16 (55.2%) cases in G2b. The results of this study confirm that cytology has an extremely varying diagnostic yield in urinary bladder TCC. Greater cell exfoliation, increased atypia, and a tendency to infiltration of G2b and G3 cases probably account for the higher diagnostic yield detected in these groups. © 1992 Wiley‐Liss, Inc.