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Working formulation of the non‐Hodgkin's lymphomas: A study of cell size and mitotic indices in cytologic subtypes
Author(s) -
Das Dilip K.,
Gupta Subhash K.,
Datta Bhoopendra N.,
Sharma Suresh C.
Publication year - 1991
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840070511
Subject(s) - medicine , mitotic index , cytology , mitosis , lymphoma , pathology , working formulation , non hodgkin's lymphoma , biology , genetics
Cell size and mitotic indices were studied in 243 nonHodgkin's lymphomas (NHL) diagnosed cytologically and classified according to the Working Formulation. Low‐, intermediate‐, and high‐grade lymphomas constituted 14.8%, 18.9%, and 61.7% of the cases, respectively. Measurement of the diameter of 100 lymphoid cells in each case showed that in most of the low‐grade malignant lymphomas, 50‐80% of the cells were small (< 10 μm). A majority of the cells (an average of 45‐60%) in intermediate‐ and high‐grade lymphomas were in the range of 11‐15 μm. Only the intermediate‐grade large noncleaved and high‐grade immunoblastic lymphomas had a majority of their cells (> 50%) larger than 15 μm. The mitotic indices (number of mitotic figures per 500 lymphoid cells) showed a highly significant difference between low‐ (0.7±1.14), intermediate‐ (3.0±2.67), and high‐grade (5.4±3.40) lymphomas using the Wilcoxon's signed rank test (P < 0.0001). Nearly two‐thirds of the cases in each grade were within specific ranges of mitotic indices, i.e., < 1 for low‐, 1‐3 for intermediate‐, and > 3 for high‐grade lymphomas.