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Pancreatic adenocarcinoma: Regression analysis to identify improved cytologic criteria
Author(s) -
Cohen Michael B.,
Egerter Daniel P.,
Holly Elizabeth A.,
Ahn David K.,
Miller Theodore R.
Publication year - 1991
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840070404
Subject(s) - medicine , adenocarcinoma , cytology , logistic regression , pancreatic cancer , biopsy , cytopathology , radiology , gastroenterology , pathology , cancer
The incidence of pancreatic adenocarcinoma is increasing and it is usually unresectable at the time of diagnosis. Consequently, fine‐needle aspiration biopsy (FNAB) is being used more frequently for diagnosis. The reported sensitivity of diagnosing pancreatic adenocarcinoma by FNAB has varied between 50% and 100%. In an attempt to increase the diagnostic sensitivity, we retrospectively reviewed a series of pancreatic FNABs. Fifteen cytologic criteria were evaluated in 78 patients who had pancreatic FNABs. Of these patients, 49 had primary adenocarcinomas and 29 had benign, non‐neoplastic lesions. Using a stepwise logistic regression analysis we identifed three key cytologic criteria for this diagnosis. Our study identifed anisonucleosis (P = 0.001). large nuclei (P = .007), and nuclear molding (P = .03) as the significant cytologic features for diagnosing pancreatic adenocarcinoma. In combination, these three criteria had a sensitivity of 98% and a specificity of 100%.