Premium
Sampling accuracy of the modified ayre spatula/zelsmyr cytobrush versus the modified ayre spatula/bulb aspirator in the collection of cells from the uterine cervix
Author(s) -
Selvaggi Suzanne M.,
Malviya Vinay
Publication year - 1991
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840070322
Subject(s) - endocervix , medicine , aspirator , cervix , cytology , gynecology , cervical intraepithelial neoplasia , uterine cervix , pathology , cervical cancer , carcinoma , cancer , physics , thermodynamics
An 8‐mo (August 1988 through April 1989) study was performed to evaluate the efficacy of the modified Ayre spatula/Zelsmyr Cytobrush versus the modified Ayre spatula/bulb aspirator in the collection of cells, both normal and abnormal, from the uterine cervix. The majority (78%) of the 192 patients, ranging in age from 18 to 82 yr, were referred to the gynecologic/oncologic clinic for follow‐up of an atypical Papanicolaou smear or of a previously diagnosed and treated cervical, vulvar, or endometrial lesion. Of the 192 patients, 149 were premenopausal (15 of whom were pregnant), 12 were perimenopausal, and 31 were postmenopausal. Patients were randomized into one of two groups based on the collection of samples for their cervical smears: 1) modified Ayre spatula (exocervix) plus Zelsmyr Cytobrush (endocervix; 90 cases) and 2) modified Ayre spatula (exocervix) plus bulb aspirator (endocervix; 102 cases). Of the smears prepared with the spatula/Cytobrush (90 cases), only 2 (2.2%) lacked endocervical cells. Within this group, the smears of 5 of 5 pregnantpatients (100%) and 13 of 13 postmenopausal patients (100%) contained endocervical cells. Cytologic abnormalities were present in 15 of these cases: koilocytosis in 4, cervical intraepithelial neoplasia (CIN)‐I in 5, CIN‐II in 4, and CIN‐III in 2. Five of the 15 cytologically positive cases had histologic verification; the cytologic findings were predictive of the histologic findings in all. Of the smears prepared using the spatula/bulb aspirator (102 cases), 26 (25.5%) lacked endocervical cells. Within this group, the smears of only 4 of 10 pregnant patients (40%) and 14 of 18 postmenopausal patients (78%) contained endocervical cells. Cytologic abnormalities were diagnosed in 23 of these 102 cases: koilocytosis in 6, CIN‐I in 12, CIN‐II in 3, and CIN‐III in 2. Fourteen of the 23 cytologically positive cases had histologic verification; cytologic underestimation of the severity of the lesion occurred in 5 cases (4 in CIN‐III and I in CIN‐II lesions). The results of this study indicate that the modified Ayre spatula/Zelsmyr Cytobrush technique is more effective than the modified Ayre spatula/bulb aspirator technique in obtaining an adequate cervical cell sample containing endocervical cells, particularly in pregnant and postmenopausal patients, and in may aid in predicting the histologic severity of the cervical lesion.