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Rhabdomyosarcomatous differentiation in a neuroblastoma: A potential pitfall in the cytologic diagnosis of small round‐cell tumors of childhood
Author(s) -
Layfield Lester J.,
Glasgow Ben J.
Publication year - 1991
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840070218
Subject(s) - medicine , rhabdomyosarcoma , neuroblastoma , desmin , pathology , fine needle aspiration , cytology , neoplasm , stromal cell , immunohistochemistry , sarcoma , biopsy , vimentin , cell culture , biology , genetics
Rhabdomyoblasts demonstrating immunoreactivity for musclespecific actin, desmin, and myoglobin were identified in smears obtained by aspiration from a large retroperitoneal mass in a 14‐mo‐old girl. Following a tentative diagnosis of a rhabdomyogenous neoplasm, retroperitoneal exploration and adrenalectomy demonstrated a stromal poor neuroblastoma with extensive rhabdomyogenous differentiation. The presence of a subpopulation of rhabdomyoblasts was not diagnostic of rhabdomyosarcoma when obtained by fine‐needle aspiration from a retroperitoneal tumor composed predominantly of primitive small round cells.