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Extrarenal primitive malignant tumor with rhabdoid features: Fine‐needle aspiration cytology, lmmunocytochemistry, and electron microscopy of a case
Author(s) -
Pettinato Guido,
Manivel J. Carlos,
d'Amore Emanuele S. G.,
Petrella Giuseppe
Publication year - 1991
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840070215
Subject(s) - cytokeratin , pathology , vimentin , desmin , cytoplasm , cytology , fine needle aspiration , hyaline , cytopathology , electron microscope , medicine , nucleolus , cytoplasmic inclusion , anatomy , biology , immunohistochemistry , biopsy , microbiology and biotechnology , physics , optics
We describe a malignant pelvic tumor with rhabdoid‐like features that arose in the sacroiliac region of a 15‐year‐old girl. Fine‐needle aspiration (FNA) cytology showed large cells with glassy cytoplasm, globular hyaline cytoplasmic inclusions, and prominent nucleoli. Immunocytochemical methods applied to FNA material revealed immunoreactivity for cytokeratin, epithelial membrane antigen, and vimentin; the cellsfailed to react with antibodies to desmin. This distinct appearance and phenotype was most consistent with a diagnosis of extrarenal malignant rhabdoid tumor. Electron microscopy confirmed this interpretation, showing whorled Jlamentous aggregates in the cytoplasm of the tumor cells.