Premium
Fine‐Needle Aspiration Biopsy Diagnosis of Endodermal Sinus Tumor: Histologic and Ultrastructural Correlations
Author(s) -
Akhtar Mohammed,
Ashraf Ali M.,
Sackey Kwesi,
Jackson Derek,
Bakry Mohammed
Publication year - 1990
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840060308
Subject(s) - pathology , ultrastructure , cytoplasm , eosinophilic , biopsy , vacuole , fine needle aspiration , medicine , hyaline , basement membrane , sinus (botany) , anatomy , biology , microbiology and biotechnology , botany , genus
Abstract Fine‐needle aspiration biopsies from five patients with endo‐dermal sinus tumors (ESTs) were reviewed, and the j'indings were correlated with histologic and ultrastructural (appearances. In the aspiration smears, two types of tumor cells were seen, forming clusters of variable sizes. Type A cells had distinct cell borders, and their cytoplasm contained onry occa‐ sional vacuoles. Type B cells had ill‐defined cell borders and formed syncytial clusters; their cytoplasm was characterized by large numbers of rounded vacuoles. The background con‐ tained patches of mucoid material and macrophages with foamy cytoplasm. Eosinophilic hyaline cytoplasmic bodies and irregular deposits of intercellular basement membrane‐like material were recognized easily in aspiration smears. These features correlated well with histologic and ultrastructural appearances. The significance of these jindings in the fine‐ needle aspiration biopsy diagnosis of EST and its distinction from other germ‐cell and non‐germ‐cell tumors is discussed.