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Fine‐needle aspiration cytology of granulocytic sarcoma and myeloid metaplasia
Author(s) -
Silverman Jan F.,
Geisinger Kim R.,
Kim Park H.,
Strausbauch Paul R.,
Frable William J.
Publication year - 1990
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840060207
Subject(s) - medicine , pathology , immunoperoxidase , cytopathology , fine needle aspiration , cytology , extramedullary hematopoiesis , myeloid , myeloid sarcoma , sarcoma , lymph node , biopsy , haematopoiesis , immunology , antibody , stem cell , biology , monoclonal antibody , genetics
The fine‐needle aspiration (FNA) cytology of two cases of granulocytic sarcoma involving the breast is reported along with the FNA cytology of one case of myeloid metaplasia (extramedullary hematopoiesis) involving an axillalry lymph node. Two patients had known myeloproliferative disorders, while granulocytic sarcoma of the breast was the initial presentation of an unsuspected acute granulocytic leukemia in the other patient. Diff‐Quik‐stained preparations aided in the diagnosis of all three cases. Immunoperoxidase stains for factor VIII‐related antigen helped confirm the megakaryocytic differentiation of the cells in the FNA cytology of myeloid metaplasia. Electron microscopic (EM) examination performed on the aspirated material also showed megakaryocytic differentiation of the bizarre cells. FNA cytology can make a specific diagnosis of granulocytic sarcoma and myeloid metaplasia. The workup of these unusual extramedullary myeloproliferative masses was aided when immunocytochemistry and EM were performed on the aspirated material.