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Fine‐needle aspiration biopsy of seminoma and dysgerminoma: Cytologic, histologic, and electron microscopic correlations
Author(s) -
Akhtar Mohammed,
Ashraf Ali M.,
Huq Mahmuda,
Bakry Mohammed
Publication year - 1990
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840060206
Subject(s) - seminoma , dysgerminoma , pathology , medicine , biopsy , fine needle aspiration , cytology , cytoplasm , epithelioid cell , biology , immunohistochemistry , ovary , microbiology and biotechnology , chemotherapy
Abstract Cytomorphologic features in a series of fine‐needle aspiration biopsies from eight patients with seminoma or dysgerminoma were reviewed, and the findings were further correlated with histopathologic and ultrastructural appearances. Three cell types were encountered. Type I was least differentiated and least frequent. Type II was most frequent and had well‐developed cytoplasm rich in organelles. Type III was similar to type II but also contained abundant cytoplasmic glycogen. In cytology smears, type III cells contained large punched‐out cytoplasmic vacuoles corresponding to the areas of glycogen deposition. The background contained a variable mixture of inflammatory cells including lymphocytes, plasma cells, epithelioid cells, and epithelioid granulomas. The significance of these findings in the diagnosis of seminoma or dysgerminoma and the distinction from other germ‐cell and non‐germ‐cell tumors is briefly discussed.