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Argyrophil carcinoma of the breast: A cytologic, histochemical, and ultrastructural study of a case
Author(s) -
Hussein K. A.,
Sanders D. S. A.,
Preece P. E.,
Hunter S. M.,
Nicoll S. M.
Publication year - 1989
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840050220
Subject(s) - ultrastructure , pathology , eosinophilic , cytology , staining , histology , carcinoma , cytoplasm , breast carcinoma , medicine , cytopathology , electron microscope , biology , breast cancer , cancer , microbiology and biotechnology , physics , optics
Aspirate from an argyrophil carcinoma (“carcinoid”) of the breast showed malignant dispersed epithelial cells. With Diff‐Quik, the cytoplasm was seen to be abundant, with prominent eosinophilic granularity. The nuclei were fairly uniform, round or oval, and eccentric and had a finely stippled chromatin pattern. On histology, the tumor appeared typical for argyrophil carcinoma, and staining with Grimelius for argyrophilic granules was positive. Membrane‐bound neurosecretory granules were seen on electron microscopy.