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Immunocytochemical localization of carcinoembryonic antigen in cerebrospinal fluid with metastatic carcinoma of the stomach: Report of four cases
Author(s) -
Iwa Nobuzo,
Yutani Chikao,
Kobayashi Tadao K.
Publication year - 1988
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840040408
Subject(s) - carcinoembryonic antigen , medicine , immunoperoxidase , pathology , cerebrospinal fluid , cytology , staining , carcinoma , gastric carcinoma , stomach , metastatic carcinoma , immunohistochemistry , antibody , cancer , monoclonal antibody , immunology
Abstract A study was undertaken to evaluate the cellular findings of gastric carcinoma in cerebrospinal fluid (CSF). Immunocytochemical localization of carcinoembryonic antigen (CEA) was performed on four cases of metastatic gastric carcinoma cells in CSF samples. A positive peroxidase‐antiperoxidase (PAP) reaction was obtained in all cases, with intense staining for CEA in the CSF samples as well as in the paraffin‐embedded tissue sections from the primary gastric tumors. Cellular morphology and the results of immunoperoxidase staining can be studied simultaneously. We believe that the PAP method for CEA increases diagnostic accuracy of cytology in the CSF.