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Renal‐cell carcinoma with intranuclear inclusions metastatic to thyroid: A diagnostic problem in aspiration cytology
Author(s) -
Gritsman Andrey Y.,
Popok Steven M.,
Ro Jae Y.,
Dekmezian Roupen H.,
Weber Randal S.
Publication year - 1988
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840040209
Subject(s) - medicine , pathology , thyroid , nephrectomy , renal cell carcinoma , metastasis , differential diagnosis , cytopathology , fine needle aspiration , cytology , thyroid carcinoma , carcinoma , thyroidectomy , metastatic carcinoma , kidney , cancer , biopsy
A case of renal‐cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal‐cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.