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Cytodiagnosis and monitoring of acute lymphocytic leukemia and eosinophilia in cerebrospinal fluid
Author(s) -
Coleman Anne,
Schumann G. Berry
Publication year - 1987
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840030415
Subject(s) - medicine , cerebrospinal fluid , lymphoblast , hypereosinophilia , pathology , acute lymphocytic leukemia , leukemia , calla , eosinophilia , acute leukemia , cytology , null cell , chronic lymphocytic leukemia , immunology , lymphoblastic leukemia , antibody , cell culture , monoclonal antibody , biology , genetics
A case of adult aleukemic leukemia with an isolated CNS relapse diagnosed by cytologic examination of the CSF is reported. CSF hypereosinophilia of uncertain significance was documented. Immunologic marker studies (CALLA, HTA, Tdt) were performed on the CSF and showed a null cell acute lymphocytic leukemia. Sequential CSF specimens were obtained to determine the continued presence of lymphoblasts. Cytologic monitoring of the CSF in acute leukemia is a useful technique to determine disease status and efficacy of therapy. We advocate the use of cell morphology for monitoring, reserving the use of cell markers for initial identification of malignant cells and for use when the cell morphology is altered. Diagn Cytopathol 1987;3:330‐4.