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Short‐term estrogen test for cytodiagnosis in postmenopausal women
Author(s) -
Kashimura Masamichi,
Baba Shinji,
Nakamura Shuji,
Matsukuma Keita,
Kamura Toshiharu
Publication year - 1987
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840030302
Subject(s) - medicine , estrogen , term (time) , test (biology) , gynecology , postmenopausal women , obstetrics , biology , paleontology , physics , quantum mechanics
A short‐term estrogen test was used to obtain a correct cytologic diagnosis in 73 patients with an equivocal atrophic cellular pattern. Overestimation in cytodiagnosis was markedly eliminated, and the correct cytologic diagnosis was made in 81 % of the cell samples after the estrogen test. The purpose of this study was not only to confirm the usefulness of the short‐term estrogen test, but also to observe the cytomorphologic changes before and after the test. Thick cytoplasm, vacuoles in the cytoplasm, and a distinct cell border increased, while the amorphous chromatin pattern was eliminated after the estrogen test. Maturation of atypical cells in cases of dysplasia, carcinoma in situ, and invasive squamous‐cell carcinoma was investigated before and after the estrogen test. Although malignant cells were not influenced by estrogen, maturation of dysplastic cells was induced after the test.