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Nuclear and cell area measurements in the cytological evaluation of pleural effusions: A study of subjective assessments and morphometric measurements
Author(s) -
Christensen Jan A.,
Skaarland Elsa
Publication year - 1987
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840030110
Subject(s) - medicine , mesothelial cell , pathology , pleural effusion , effusion , carcinoma , ovarian carcinoma , mesothelioma , nuclear medicine , radiology , ovarian cancer , cancer , surgery
Morphometric measurements of cellular area, nuclear area and nuclear:cytoplasmatic ratio were performed on single cells in pleural effusions from 15 patients with effusion caused by bronchial, ovarian, or mammary carcinoma. The results were compared with corresponding measurements on mesothelial cells in pleural effusions from 15 patients without malignant disease. Significant differences were found between the mean values from cellular area, nuclear area, and nuclear:cytoplasmatic ratios in mesothelial cells from benign effusion versus malignant cells from effusions associated with metastatic growth. Such morphometric measurements are, however, of little value in routine diagnostic work as more than 90% of the cells in the two groups showed similar values. Diagn Cytopathol 1987;3:50–54.