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Cytology of hepatocellular carcinoma
Author(s) -
Gupta Subhash K.,
Das Dilip K.,
Rajwanshi A.,
Bhusnurmath S. R.
Publication year - 1986
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840020405
Subject(s) - pathology , hyaline , giemsa stain , medicine , cytology , hepatocellular carcinoma , staining , glycogen , cytoplasm , carcinoma , biology , biochemistry
Twenty‐five cases of cytologically and histologically confirmed hepatocellular carcinoma (HCC) were cytomorphologically analyzed using May‐Grünwald‐Giemsa (MGG)‐stained aspiration smears and supplemented with special stains. The cell types were categorized as well differentiated (18 cases), vacuolated (four cases), giant cell (one case), and poorly differentiated (two cases). Glycogen staining was positive in 80% of the cases and hence served as a reliable parameter of diagnostic importance in HCC. Cytoplasmic hyaline bodies (14.6%) and bile pigment (17%), when present, were other important features supporting the diagnosis of HCC. Vacuolation of the cell cytoplasm (80%) was possibly related to glycogen accumulation. The cause of nuclear vacuolation (60%) and the significance of nuclear argyrophilia as markers of abnormal cell growth remain to be studied. Diagn Cytopathol 1986;2:290‐294.