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Immunodetection of neuron‐specific enolase and keratin in cytological preparations as an aid in the differential diagnosis of lung cancer
Author(s) -
Kyrkou Kalliopi A.,
Latridis Sotirios G.,
Athanassiadou Pauline P.,
Lambropoulou Sofia,
Liossi Anna
Publication year - 1986
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840020308
Subject(s) - enolase , keratin , pathology , immunostaining , carcinoma , medicine , small cell carcinoma , lung cancer , keratin 8 , lung , cell , small cell lung carcinoma , immunohistochemistry , biology , genetics
The results of neuron‐specific enolase (NSE) and keratin immunodetection in cytological specimens of sputum secured from 41 patients with lung cancer are presented. All 19 cases of small‐cell carcinoma showed intense immunoreactivity for NSE. No such immunoreactivity was found in 21 of 22 cases of non‐small‐cell carcinoma. The single positive result was from a case of large‐cell undifferentiated carcinoma. All 10 cases of squamous‐cell carcinoma showed immunoreactivity for keratin. The 19 cases of small‐cell carcinoma showed no such reactivity. Our findings indicate that immunostaining for NSE and keratin is a valuable aid when a definite diagnosis of small‐cell carcinoma of the lung can not be made on the basis of conventional cytologic features. Diagn Cytopathol 1986;2:217‐220.