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Cytopathology of mesenchymal repair
Author(s) -
James L. Patrick
Publication year - 1985
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2840010204
Subject(s) - cytopathology , mesenchymal stem cell , medicine , pathology , connective tissue , malignancy , biopsy , cytology , regeneration (biology) , tissue repair , biology , microbiology and biotechnology , biomedical engineering
Tissue repair is a common biologic process closely associated with the inflammatory response. The cytologic features of regeneration and repair of epithelial surfaces have been intensely studied and documented. Regeneration and repair occur in mesenchymal tissues and their radiographic and cytologic findings may closely simulate malignancy. This paper reviews the cytologic features of mesenchymal repair as seen in 44 aspiration biopsy specimens of bone, skeletal muscle, fibroadipose tissue, and fibrous connective tissue. In general, cytologic specimens from such lesions display variable but often scanty cellularity, prominent cellular heterogeneity with a spectrum of atypical features, an admixture of reactive fibroblasts, and evidence of a coexisting inflammatory reaction. Careful attention to cytologic detail and review of clinical and radiographic findings are mandatory in the evaluation of these specimens.