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Non‐neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung
Author(s) -
Nelson Blessie Elizabeth,
Hong Angelina,
Okereke Ike,
Markowitz Avi,
Willis Maurice,
Muthukumarana Palawinnage V.,
Nawgiri Ranjana
Publication year - 2021
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24846
Subject(s) - medicine , nivolumab , malignancy , inflammatory pseudotumor , melanoma , lung , biopsy , immunotherapy , pathology , radiology , cancer , lesion , cancer research
Nivolumab is commonly used as monotherapy or in combination therapy for management of locally advanced or metastatic melanoma; however, it is also associated with immunotherapy‐related adverse events concerning for disease progression or tumor flare reaction. This report presents a case of a non‐neoplastic pseudotumor of the lung initially mistaken for malignancy that occurred in a patient receiving adjuvant nivolumab therapy following complete resection of stage IIIB melanoma. The diagnosis was made by lung biopsy and confirmed by a wedge resection, with findings consistent with organizing pneumonia type of pulmonary inflammatory pseudotumor rather than malignancy.