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Cytopathologic findings in histiocytic sarcoma of thyroid mimicking as anaplastic carcinoma: A report of a rare case with review of literature
Author(s) -
Gupta Deepika,
Gupta Aanchal,
Nalwa Aasma,
Yadav Taruna,
Chaudhary Ramkaran,
Rao Meenakshi
Publication year - 2021
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24679
Subject(s) - histiocytic sarcoma , medicine , pathology , anaplastic carcinoma , sarcoma , histiocyte , thyroid , vimentin , immunohistochemistry , neoplasm , lymph node , thyroid neoplasm , thyroglobulin , cytopathology , thyroid carcinoma , carcinoma , cytology
Background Histiocytic sarcoma is an extremely rare malignant hematological histiocytic neoplasm which is a diagnosis of exclusion based on its morphological and predominantly immunohistochemical criteria. Case Description and Diagnosis A 63‐year female presented with complaints of a midline neck swelling along with right sided neck swelling. On fine‐needle aspiration (FNA) from the thyroid lesion and the right cervical lymph node, the smears showed similar findings and a provisional morphological diagnosis of malignant spindle cell neoplasm was kept. On immunohistochemistry, the tumor cells showed immunoreactivity for vimentin, CD45, CD 68 and fascin and were immunonegative for thyroglobulin, S100, CD21, CD3, CD4 and other markers. Based on the immunohistochemical profile, a diagnosis of histiocytic sarcoma was established. Conclusion Histiocytic sarcoma is a rare malignant neoplasm that can be easily missed in thyroid resembling an anaplastic carcinoma.