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A bronchial mucous gland adenoma harboring GNAS R201C mutation
Author(s) -
Kojima Ryuji,
Morimoto Junichi,
Ishida Yasuo,
Sugano Isamu,
Yamazaki Kazuto
Publication year - 2021
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24674
Subject(s) - gnas complex locus , medicine , pathology , adenoma , carcinogenesis , differential diagnosis , mutation , tubular adenoma , gene , cancer , biology , genetics , colorectal cancer , colonoscopy
We present a case of bronchial mucous gland adenoma (MGA) and discuss the results of its cytomorphological and cytogenetic examination serving as a basis for the differential diagnosis. To our best knowledge, this is a first report that demonstrate a GNAS gene (R201C) mutation in mucous gland adenoma, which may play an important role in MGA tumorigenesis, as is the case in other mucinous‐type epithelial neoplasms of various organs.