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Metastatic low‐grade endometrial stromal sarcoma after 24 years: A case report and review of recent molecular genetics
Author(s) -
MindiolaRomero Andres E.,
Liu Xiaoying,
Dillon Jessica L.,
Talarico Michael,
Smith Geoffrey,
Zhang Linsheng,
Linos Konstantinos
Publication year - 2021
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24601
Subject(s) - medicine , endometrial stromal sarcoma , stromal cell , differential diagnosis , sarcoma , pathology , lung , stromal tumor , immunohistochemistry , molecular genetics , biology , biochemistry , gene
Low‐grade endometrial stromal sarcoma (LGESS) is a rare malignant uterine tumor with the potential to metastasize years after the primary resection. There is a broad differential diagnosis for endometrial stromal sarcomas (ESS), including both benign and malignant entities. Herein, we present the case of a 64‐year‐old female with metastatic LGESS to the lung, diagnosed by cytology, 24 years after her initial presentation. This report discusses the cytomorphologic and histopathologic characteristics, and ancillary studies including immunohistochemical stains and recent advances in molecular diagnostics of ESS. Accurate diagnosis of spindle cell lesions in the lung can be challenging. As such, this case highlights the instrumental role of ancillary testing and molecular diagnostics to achieve a more definitive diagnosis.