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Cell‐block as ancillary tool for the diagnosis of cystic and cyst‐like jaw lesions
Author(s) -
Melo Gilberto,
Mello Fernanda Weber,
Mesquita Ricardo Alves,
Grando Liliane Janete,
Rivero Elena Riet Correa
Publication year - 2020
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24400
Subject(s) - medicine , concordance , cohen's kappa , biopsy , kappa , cyst , radiology , confidence interval , radiography , pathology , linguistics , philosophy , machine learning , computer science
Abstract Background The cell‐block technique is a cytological diagnostic method that decreases cellular dispersion; however, its usefulness regarding intraosseous lesions is underexplored. Therefore, this study aimed to assess the diagnostic usefulness of cell‐block for cystic and cyst‐like jaw lesions. Methods Individuals with cystic or cyst‐like jaw lesions who underwent aspiration biopsy were considered eligible. Aspiration of luminal content was prepared and processed by the cell‐block technique. Cytological evaluations were blindly performed by two trained PhD students (in a single evaluation) and one oral and maxillofacial pathologist (OMP). Cohen's kappa statistic was used to measure inter‐rater agreement. Results The sample was composed of 52 lesions, represented by 25 radicular cysts (RC), 17 odontogenic keratocysts (OKC), 5 idiopathic bone cavities (IBC), and 5 unicystic ameloblastomas (UA). The kappa coefficient of cell‐block compared to histopathological diagnosis was 0.390 (95% confidence interval [95%CI], 0.195‐0.585) for PhD students and 0.612 (95%CI, 0.433‐0.791) for the OMP. The highest concordance rates between cell‐block and histopathological diagnosis were observed for RC (PhD = 76.0%; OMP = 80.0%) and OKC (PhD = 58.8%; OMP = 76.5%). Conflicting results were found regarding IBC (PhD = 40.0%; OMP = 80.0%) and UA, that presented the overall lowest concordance rates (PhD = 20.0%; OMP = 40.0%). Conclusion The cell‐block technique presented a high diagnostic usefulness for detecting RC and OKC and, if associated with clinical and radiographic characteristics, might be sufficient for final diagnosis of these diseases. Regarding IBC and UA, an analysis with a higher number of cases is recommended to determine the true usefulness of the cell‐block as ancillary tool for the diagnosis of these lesions.