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Pleural metastasis from auricular melanoma: A brief report
Author(s) -
Straccia Patrizia,
Martini Maurizio,
Pierconti Francesco
Publication year - 2020
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24370
Subject(s) - medicine , melanoma , metastasis , pathology , sanger sequencing , immunohistochemistry , lymph , malignant pleural effusion , metastatic melanoma , sarcoma , cancer research , cancer , mutation , lung cancer , biochemistry , chemistry , gene
Primary auricular melanoma is rarely reported. Approximately, it accounts for 1% to 4% of all cutaneous melanoma. Early literature suggested that melanoma of the ear is more aggressive than other melanomas, with a propensity for spreading to both regional lymph nodes and distant sites. Here, we present a case of cytological pleural metastasis from auricular melanoma in a 43‐year‐old woman. Immunohistochemical staining showed that the tumors cells were positive for S‐100 protein and Melan‐A. The mutation of the v‐raf murine sarcoma viral oncogene homolog B (BRAF) V600E was demonstrated on Sanger sequencing. To our knowledge, this is the first report describing the cytomorphology of metastatic auricular melanoma in pleural effusion.